Description
Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed: 24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed: 16456148, PubMed: 25242865). Also has anti-fibrotic activity in lung (PubMed: 24213919, PubMed: 26559674). May play a role in fetal lung development and maturation (PubMed: 18535256). Promotes branching morphogenesis during early stages of lung development (PubMed: 18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed: 24514953)